As a distinguished Professor in the Department of Chemical and Biological Engineering at the South Dakota School of Mines, I have taught 15 different courses to undergraduate and graduate students and tried to integrate Engineering Sciences with Biological Sciences. My research expertise includes Rules of Life in Biofilms grown on 2D materials, Extremophilic Bioprocessing of Solid Wastes to Biofuels and Value-added Products, Space Biology, Genome Editing, Biocatalysis, and Biomaterials/Biopolymers, Over the past 16 years, I have acted as the PI or co-PI on over $54.8 million in funded research. I have two patents, and thirteen invention disclosures, published over 112 peer-reviewed articles in high-impact factor journals, and have contributed to 34 book chapters. I have edited 11 books for Springer International Publishing AG, Wiley, and ACS publications. I am most passionate about Extremophiles – the small – but mighty microorganisms that thrive in the planet’s harshest environments. My lab has been investing in finding, growing, and applying other extremophiles for more innovative applications such as –Psychrophiles (cold-loving) for the stabilization of civil construction buildings and Alkalohalophiles (salt/high pH-loving) and Barophiles (high pressure-loving) bugs for carbon dioxide mineralization, and Thermophiles (hot-loving) for biomaterials for agriculture and drug delivery applications.